While both PSP–Richardson’s syndrome and amyloid-negative CBS are highly correlated with a 4R-tauopathy at post-mortem, both from our local brain bank and internationally,26,27,72 other pathologies are possible, and so are coexistent pathologies that may synergistically contribute to neurodegeneration.73 The gene discussed is CBS; the disease is supranuclear palsy, progressive, 1.