In post-mortem studies of the tauopathy Alzheimer’s disease, there is a biphasic synaptic protein response during disease progression, with increases in synaptophysin/syntaxin/SNAP-25 in early Braak stages and synaptic loss observed only when the disease has progressed to the neocortex.19 This evidence concerns the gene SYP and early-onset autosomal dominant Alzheimer disease.