On relative risk estimation, age ≥ 60 years, presence of multiple co-morbidities, increased baseline inflammatory markers (IL-6 and D-dimer), high CT severity index and development of systemic complications like lung fibrosis, arrhythmia, encephalopathy, thrombocytopenia and hypotension were significant risk factors associated with death. The gene discussed is IL6; the disease is Encephalopathy.