In chronic active Epstein–Barr virus disease and human immunodeficiency virus (HIV) infection, LAIR-1 expression on NK cells and B cells is decreased.[20] Moreover, LAIR-1 is involved in the pathological process of inflammation in systemic lupus erythematosus and rheumatoid arthritis.[21–23] Interestingly, some studies found that abnormal LAIR-1 expression in malignant tumors, including that in HCC,[24] epithelial ovarian cancer,[25] and oral squamous cell carcinoma, is related to prognosis.[26] Furthermore, LAIR-1 plays an important role in tumor immune escape.[27]. This evidence concerns the gene LAIR1 and oral cavity squamous cell carcinoma.