LAIR1 and Cirrhosis: Li et al. found that the cytolytic capacity of NK cells in GZ is higher than that in the HCs and IA patients.[31] Previous studies demonstrated that a sizable fraction of the GZ patients (9%) can show progression to cirrhosis; therefore, early initiation of treatment is necessary to induce HBV immune control and avoid poor prognosis.[35] High expression of LAIR-1 in GZ patients suggests that T cells are at a lower activation level and may be difficult to activate, owing to which the antiviral effects in the GZ patients are usually not satisfactory.