Univariate logistic regression analysis showed that age, hypertension, SOFA score, and the levels of IL-6, WBC, NE, LYM, red blood cell, hs-CRP, DBIL, ALP, GGT, urea nitrogen, uric acid, cystatin C, sodium, chlorine, phosphorus and CK-MB were related to the aggravation of the patient's condition. Here, CST3 is linked to Hypertension.