SIRT3 and neurodegenerative disease: It was found SIRT3 could regulate mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.[12] Other studies demonstrated that SIRT3 played multiple roles in cardiovascular diseases,[13] cancer,[14] and neurodegenerative diseases.[15] In recent years, SIRT3 is found to show anti-inflammation activity in many diseases.[16] However, up to now, no study focused on clinical significance of SIRT3 in severe CAP patients.