SIRT3 and neurodegenerative disease: It has been found in cardiovascular diseases, SIRT3 protects heart from metabolic dysfunction by regulating glucose and lipid metabolism and making balance for myocardial ATP.[22] In neurodegenerative disease, SIRT3 also shows its anti-oxidative stress activity.[15] It is well-known that there is crosstalk between inflammation and oxidative stress, in which activated oxidative stress might induce release of pro-inflammatory factors.[23] Thus, it is not surprise for SIRT3 to show its anti-inflammatory activity in multiple diseases.