It was found that SIRT3 could improve inflammation in endotoxin-induced acute lung injury.[18] The activation of SIRT3 showed anti-inflammation activity in both liver and renal injury.[19,20] In a recent study, Dikalova et al[21] also found that the deficiency of SIRT3 might be associated with vascular dysfunction, increased vascular inflammation and oxidative stress in hypertension. Here, SIRT3 is linked to hypertensive disorder.