Pathological examination revealed morphological and immunohistochemical findings in line with metastatic renal cell carcinoma, including positive staining for AE1/AE3 vimentin and CD10, partial positive for RCC, PAX-8, and negative staining for inhibin, CgA, and CA9, the index of Ki-67 is 5%. This evidence concerns the gene MKI67 and renal cell carcinoma.