COL18A1 and neoplasm: Folkman first proposed that antiangiogenesis agents can inhibit tumor growth.[29] Endostatin can significantly inhibit the proliferation and migration of vascular endothelial cells, leading to the apoptosis of vascular endothelial cells.[6] As such, it can prevent tumor cells from receiving the nutrients necessary for growth and metastasis.[6] Recombinant human endostatin (Endostar) is an antiangiogenesis agent that was developed independently in China.