In contrast, patients with Lepromatous leprosy (LL) present a greater humoral immune response, characterised by multiple lesions, high bacterial load, diminished or absent lymphocyte proliferation.[6,7] The innate immune response to M. leprae infection involves both TLR1, TLR2 and NOD-like receptors.[8,9] Various cytokines such as IFN-γ, IL-10 generated by the innate immune response have important roles against infection.[10] The up-regulate production of various cytokine persist in leprosy patient even if M. leprae is controlled by MDT.[11,12]M. Here, IL10 is linked to leprosy.