IDH1 and germ cell tumor: The expression of CCNF is elevated in oral cancer according to 1 report, and the logFC value was 2.3956.[22] In regard to investigating the significance of the let 7 families of tumor suppressor microRNAs in malignant germ cell tumors, some researchers found that CCNF and let 7 expressions were negatively correlated, and CCNF was considered by the researchers to be an oncogene gene.[23] Under metabolic stress conditions, CCNF promotes the degradation of RBPJ, and RBPJ can regulate IDH1, which is often mutated to an oncogenic form, IDH1-R132H, in cancers.