CCNF and ovarian carcinoma: CCNF can accelerate proliferation and increase in vitro tumorigenicity of ovarian cancer cells, and loss of CCNF results in severe mitotic defects, multipolar spindles, and supernumerary centrosomes, finally leading to the induction of apoptosis in ovarian cancer cells.[20] The above abnormal phenotypes are seen consistently in different cancer models, indicating that CCNF has a general correlation with human cancer.