For instance, the level of cyclin B2 was higher in HCC than normal tissues and was associated with a poor prognosis in HCC patients.[17] High cyclin D1 expression accompanied by low autophagic activity was correlated with liver tumor formation and poor survival in HCC patients.[18] However, no CDKs interacting with CCNF have yet been found. This evidence concerns the gene CCNF and hepatocellular carcinoma.