Unlike normal cells that transiently express small amounts of cyclin proteins at specific points in the cell cycle, many tumor cells have high constitutive levels of 1 or more cyclins.[25] Here, we revealed that CCNF maybe can be used as a biomarker or a prognostic predictor for its elevation in HCC and negatively correlation with prognosis. This evidence concerns the gene CCNF and hepatocellular carcinoma.