After the occurrence of PCOS, hyperinsulinemia interacts with insulin-like growth factors in the ovary, causing the follicular membrane cells to fail to convert androstenedione into estrogen, which increases androgens and forms hyperandrogenemia.[25,26] Studies[27–29] have found that androgens can promote the apoptosis of pancreatic β cells. Here, INS is linked to Hyperinsulinemia.