Increased insulin levels can inhibit the production of SHBG in the liver and reduce the synthesis of SHBG in the liver.[32,33] The decrease of SHBG in the circulatory system makes the level of sex hormones disorder, causing glucose and fat metabolism disorders, further aggravating insulin resistance, and leading to the occurrence of GDM.[34,35]. The gene discussed is SHBG; the disease is gestational diabetes.