Two cases were suspected to be associated with hypersensitivity to sugammadex, as indicated by serum tryptase level and/or skin prick test.[12,15] Another case was clinically diagnosed with hypersensitivity to sugammadex with tryptase and IgE levels within the normal range.[17] These patients immediately experienced erythema, hypotension, or desaturation following the administration of sugammadex. The gene discussed is IGHE; the disease is Erythema.