A hallmark of carcinogenesis is the ability of cancer cells to evade apoptosis and continuously proliferate despite their abnormalities.[14]The PI3K/Akt and MAPK signaling pathways drive carcinogenesis through their pro-proliferation and anti-apoptotic functions.[15,16] phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) is a class I PI3K catalytic subunit. Here, PIK3CA is linked to cancer.