In addition, Chadwick et al reported that PTEN was largely absent in high-grade angiosarcomas, while pMAPK was activated in all tumors of vascular origin.[22] These results were in agreement with our findings that PTEN was downregulated and pMAPK was upregulated in scalp and face angiosarcoma compared with hemangioma. This evidence concerns the gene PTEN and angiosarcoma.