PROMs that assess the treatment experience in general [168] or specifically the level of satisfaction with treatment [79] or treatment burden [169] or treatment with specific modalities of treatment (eg, with pharmacotherapy [169] or insulin therapy [170]).Examples of domains assessed include efficacy, treatment burden and symptoms (side effects), diabetes worries, perceptions of insulin therapy, treatment satisfaction, and inhaler performance. This evidence concerns the gene INS and diabetes mellitus.