Previous studies indicate that PROTACs can initiate protein degradation very fast, although the time points vary broadly from 1 to 16 h after degrader exposure.[23] Our data demonstrated that LEF1 OP‐V1 and ERG OP‐C‐N1 induced the initiation of degradation of LEF1 and ERG proteins at 12 and 24 h, respectively in prostate cancer cell lines examined. The gene discussed is ERG; the disease is prostate cancer.