Complexed with β‐catenin, LEF1 promotes the transcription of Wnt target genes.[9] LEF1 also can facilitate epithelial‐mesenchymal transition (EMT).[10] Aberrant expression of LEF1 is implicated in several cancer types and related to cancer cell proliferation, migration, and invasion.[11] Therefore, therapeutic targeting LEF1 is urgently necessary to treat prostate cancer patients effectively. The gene discussed is LEF1; the disease is prostate carcinoma.