According to the functional annotation in GO database, gene promoters gaining H3K9ac were mostly enriched for biological processes (BP) terms associated with autophagy of nucleus (ATG4C, ATG12), positive regulation of DNA‐templated transcription (SUPT4H1, ALYREF), and macrophage chemotaxis (MMP28, CX3CR1) (Figure 5D; Table S2), which are closely associated with the activation of astrocytes in neuropathic pain. Here, ATG4C is linked to neuropathic pain.