Protein sequence alignments between LRK-1 and LRRK2 demonstrate that many key residues mutated in LRRK2 PD, or synthetically mutated to ablate catalytic activity, are conserved in C. elegans LRK-1 [132,133], implicating potential functional conservation between LRK-1 and LRRK2 (Figure 4). The gene discussed is LRRK2; the disease is Parkinson disease.