RAB29, also known as RAB7L1, has been a consistent PD GWAS hit [24] and the RAB29 protein has been shown to act upstream of LRRK2 [179], while RAB3, RAB5, RAB8, RAB10, RAB12, RAB35 and RAB43 have been demonstrated to be downstream effector substrates regulated by LRRK2 phosphorylation [180]. Here, LRRK2 is linked to Parkinson disease.