C. elegans strains overexpressing the PD associated LRRK2G2019S and LRRK2R1441C mutant proteins in neurons show reduced survival in response to oxidative stress induced by the environmental toxins rotenone and paraquat, widely used in toxin-based models of PD [155], when compared with animals expressing wild-type LRRK2 [142,148]. The gene discussed is LRRK2; the disease is Parkinson disease.