LRRK2 and Alzheimer disease: Meanwhile, tau is a prominent player in multiple neurodegenerative conditions including AD [110], progressive supranuclear palsy (PSP) [111] and frontotemporal dementia (FTD) [112]; hence, study of LRRK2 with its associated tauopathy and Lewy body aggregation may be applicable to a range of neurodegenerative conditions.