These cases, referred to as Lynch-like syndrome, could represent true Lynch syndrome-related cancers associated with germline MMR gene variants that are cryptic to current technologies, dMMR cancers associated with biallelic somatic variants/aberrations in the MMR or other pathway-related genes, or, more rarely, on the basis of pathogenic germline variants in other cancer predisposition genes (e.g., POLE/POLD1 and MUTYH) (15–17). This evidence concerns the gene POLD1 and cancer.