ALB and early-onset autosomal dominant Alzheimer disease: Interestingly, dilution of old plasma with saline plus albumin improved brain health and function in mice[76, 77] and attenuated progression of Alzheimer's disease in clinical trials.[78] Albumin is known to change erythrocyte aggregation and sedimentation,[79] thus it might preferentially sequester, neutralize, or buffer damaged old erythrocytes, thereby diminishing their negative effects on the BBB.