CXCL8 and Multiple Organ Failure: The high-level activation of immune cells results in a high production of inflammatory cytokines (ie, IL-6, IL-2R, IL-7, IL-8/CXCL8, IP10, MCP-1/CCL2, MIP1A/CCL3, TNF-α) that encounters a lack of anti-inflammatory pattern required to fine tune the cytokine-driven response, eliciting acute lung damage and fatal multiple-organ failure (6).