BPIFB4 and COVID-19: Even though the cellular mechanism and the regulatory circuits by which LAV-BPIFB4 induces a homeostatic response are still unknown, the relevance covered by the biphasic immune responses (protective and self-limiting) and the fine tuning of cytokines milieu might in part explain the beneficial effect achieved by LAV-BPIFB4 in the context of COVID-19.