Of note, the lack of correlations between circulating concentrations of BPIFB4 and other inflammatory markers (CRP, LDH, ferritin, D-dimer, lymphocyte count, etc., data not shown) may be consistent with the hypothesis that the low levels of BPIFB4 in high-grade COVID-19 patients may represent at most the cause and not the consequence of the disease. The gene discussed is BPIFB4; the disease is COVID-19.