Common protein kinase signaling pathways by these compounds should be prioritized for investigation into the mechanisms behind PKI-associated cardiotoxicity.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: The PKIs ibrutinib, ponatinib, nilotinib, ribociclib, trametinib, osimertinib, and idelalisib were each associated with an increased ROR for AF. Here, WEE1 is linked to atrial fibrillation.