TARDBP and amyotrophic lateral sclerosis: Some ALS-causing gene mutations encode RBPs, including transactive response DNA-binding protein 43 (TARDBP, which encodes TDP-43), fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1).