Our survival analysis indicated SUDEP first occurred after two months of age in both male and female mutants (Fig. 1), which is four to six weeks later than common monogenic developmental epileptic encephalopathy SUDEP models, such as Scn1a, Scn8a and Kcna1 mutants.45–48. Here, KCNA1 is linked to developmental and epileptic encephalopathy.