APOB and cardiovascular disorder: Accumulation of lipoproteins containing, e.g., apo-B, apo-E, and apo-C3 apolipoproteins, in the arterial wall accelerates the accumulation of macrophages, the formation of foam cells, and the process of atherogenesis [13] Thus, apolipoprotein-B (apo-B), a carrier protein of low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL), seems to be a marker of cardiovascular disease risk, but its practical usefulness is limited mainly due to the cost of determination [12].