Increased plasma renalase demonstrates to be an independent predictor of ischemia induced by exercise stress testing on top of evaluated cardiac remodeling biomarkers (sST2, galectin-3, GDF-15, and syndecan-1) and cystatin C, but does not reach plasma BNP, in both analyzed groups, the cohort of the total HF and HFrEF phenotype. Here, LGALS3 is linked to hydrops fetalis.