Increased plasma renalase demonstrates to be an independent predictor of ischemia induced by exercise stress testing on top of evaluated cardiac remodeling biomarkers (sST2, galectin-3, GDF-15, and syndecan-1) and cystatin C, but does not reach plasma BNP, in both analyzed groups, the cohort of the total HF and HFrEF phenotype. This evidence concerns the gene CST3 and hydrops fetalis.