NPPB and hydrops fetalis: For instance, the most recent study (37) evidenced that BNP did not increase discrimination for diastolic dysfunction in the HF cohort, whereas among the four biomarkers evaluated (BNP, Gal-3, sST2, and N-terminal propeptide of procollagen type III), galectin-3 demonstrated better discriminatory potential compared to that in BNP.