RNLS and intermediate coronary syndrome: Moreover, substantial evidence showed that functional polymorphisms of the renalase gene were associated with cardiac hypertrophy in patients with aortic stenosis (8) and an increased risk of CAD in the general population (9) and in hemodialyzed patients (10), patients with hypertension and associated CAD (11), patients with unstable angina pectoris and concomitant metabolic syndrome (12), and in patients with stable CAD, presenting with cardiac hypertrophy, ventricular dysfunction, and inducible ischemia (13).