Breast invasive carcinoma had the highest amplification frequency (6%) and sarcoma had the highest fusion frequency of COL1A1. It is noteworthy that all mesothelioma cases had copy number amplification (4.6%) and all uveal melanoma had deletion of COL1A1 (1.25%) (Figure 3A). The gene discussed is COL1A1; the disease is invasive breast carcinoma.