Reln was reported to be related to liver fibrosis (Mansy et al., 2014), and Ntrk2 encodes a tyrosine kinase receptor, TrkB, which is abundantly expressed in lung tissue and responsible for hypoxia, thus promoting the proliferation of pulmonary arterial smooth muscle cells (Kwapiszewska et al., 2012). This evidence concerns the gene RELN and Hepatic fibrosis.