NTRK2 and Hepatic fibrosis: Reln was reported to be related to liver fibrosis (Mansy et al., 2014), and Ntrk2 encodes a tyrosine kinase receptor, TrkB, which is abundantly expressed in lung tissue and responsible for hypoxia, thus promoting the proliferation of pulmonary arterial smooth muscle cells (Kwapiszewska et al., 2012).