In addition, SCEC and SCLC display notably similar patterns of gene-interactive networks with CENPF, NEK2, KIF11, TMPO, and FOXM1 as common skeletons centered by NUF2. In terms of the gene expression profile, the characteristics of SCEC are unique but more closely resembled SCLC than EAC/ESCC, as they share similar signaling pathways and gene-interactive networks. Here, CENPF is linked to esophageal squamous cell carcinoma.