Despite synergistically enhancing the effect of paclitaxel against paclitaxel-resistant cervical cancer cells, alkaloids from Piper nigrum could also enhance mitomycin-C (MMC) therapy of human cervical cancer through suppression of Bcl-2 signaling pathway via inactivation of STAT3/NF-κB (74). This evidence concerns the gene NFKB1 and cervical cancer.