In the same line, in another subset of the OCTABAIX cohort, subjects with previous CVD and cognitive decline presented higher concentrations of the antifibrinolytic proteins alpha-2-antiplasmin (A2AP) and coagulation factor XIII-B-chain (FXIIIB) compared to non-CVD subjects with preserved cognition and functionality (Cubedo et al., 2015). The gene discussed is F13B; the disease is Mental deterioration.