Multivariate analysis suggests that the methylation status of CADM1 (Hazard ratio HR = 2.788; 95% confidence interval: 1.043–5.063; P = 0.010) is an independent prognostic factor in disease-free survival (DFS) of HCC patients after LT (Zhang et al., 2011). This evidence concerns the gene CADM1 and hepatocellular carcinoma.