TSC2 and acute myeloblastic leukemia with maturation: To further determine whether ovarian steroids regulate TSC2 expression and subsequent mTOR activity and autophagy induction, we isolated glandular epithelial cells from the control subjects and AM patients and examined the effects of E2 and P4 on TSC2, LC3-II/LC3-I, and phosphorylated mTOR expression in cultured normal HEECs (nHEECs) and AM HEECs (aHEECs).