It was revealed that the hyper-accessible regions associated up-regulated DEGs were significantly enriched in small cell lung cancer, cell cycle, MAPK and Rap1 signaling pathways, while the hypo-accessible regions associated down-regulated DEGs mainly involved in endocrine resistance, lysosome, breast cancer, TGF-beta and p53 signaling pathways (Supplementary Figures 2, 4A). The gene discussed is TP53; the disease is breast carcinoma.