SPDEF and breast cancer: Up-regulation of GSTP1 maintains resistance to doxorubicin through inhibition of PI3K/AKT/mTOR activity to promote autophagy in breast cancer cells (Dong et al., 2019); Simultaneously, there were a lot of significantly down-regulated genes in MCF7-DR cells, including trefoil factor 1 (TFF1), ubiquitin B (UBB), and SAM pointed domain containing ETS TF (SPDEF).