MAPT and early-onset autosomal dominant Alzheimer disease: Once detached, tau accumulates in neurites and neuronal cell bodies, where it forms insoluble intracellular aggregates or inclusion bodies such as neurofibrillary tangles (NFTs), which are one of the major pathological features of Alzheimer’s disease (AD) (Lee et al., 2001; von Bergen et al., 2005; Zhang et al., 2009).