We compared the expression of miR-92b-3p in HER2– and HER2+ BC cells, and miR-92b-3p was obviously higher expressed in HER2+ BC cells than that in HER2– BC cells (Supplementary Figure 4B), indicating that miR-92b-3p- dependent RISCI manner on circCDYL may exhibit more effect in HER2+ BC cells than in HER2– BC cells. Here, ERBB2 is linked to breast cancer.