AGO2 and breast cancer: When silencing either AGO2 or GW182 in MCF-7 and MDA-MB-231 cells, miR-92b-3p mimic transfection exhibited slight effect on circCDYL expression (Supplementary Figure 4A), indicating that miR-92b-3p- dependent RISC manner in degradation of circCDYL existed in HER2– BC cells as well as in HER2+ BC cells.