However, it must be noted that HIF-1 signaling can facilitate amyloidogenic processing of the amyloid-beta precursor protein, leading to an increased risk of AD in people with ischemia (Zhang X. et al., 2007; Ogunshola and Antoniou, 2009; Lee H.J. et al., 2016; Kim et al., 2017). This evidence concerns the gene APP and Alzheimer disease.