For example, in renal carcinoma cells HIF-1 negatively regulates mitochondrial biogenesis via inhibition of transcriptional activity of transcriptional factor c-Myc by the expression of MAX-interacting protein 1 (MXI-1) inhibiting the Myc transcriptional activity and increased c-Myc degradation by the proteasome (Zhang H. et al., 2007). The gene discussed is MXI1; the disease is renal carcinoma.