PSEN2 and retinitis pigmentosa 1: The wild type prpf31 mRNA rescued the embryonic lethality induced by AD5 (c.1115_1125 del), however, AD5 (c.1115_1125 del) mutant RNA was not able to rescue the prpf31 morphant phenotype, but instead aggravated the MO phenotypes, indicating that AD5 acts in a dominant-negative fashion in RP pathogenesis.