For decades the “amyloid cascade hypothesis,” proposing that an accumulation of toxic amyloid beta (Aβ) plaques and twisted strands of hyperphosphorylated tau (tangles) in the brain, has been the dominant hypothesis of AD pathology (Hardy and Higgins, 1992; Park et al., 2009; Mawuenyega et al., 2010; Holtzman et al., 2011). Here, MAPT is linked to Alzheimer disease.