For instance, in the Eu-myc + lymphoma mouse model, the secretion of fibroblast growth factor-4 (FGF4) by lymphoma cells and its binding to the cognate receptor FGFR1 on endothelial cells prompts Notch ligand Jagged1 (Jag1) expression by these cells. The gene discussed is FGFR1; the disease is lymphoma.