CXCR4 and neoplasm: FL tumor cells expressing CXCR4, CXCR5 and CCR7 home in both BM and LN, and the interaction of CXCR12 expressed on BM stromal cells of the lymph node/BM with CXCR4 expressed by tumor cells, has been found to play a critical role in this context (Ame-Thomas et al., 2007).