In a series of other studies, B-cell receptor (BCR)-mediated signaling together with constitutive activation of Bruton’s tyrosine kinase (BTK) and Spleen Associated Tyrosine Kinase (SYK) are linked to cell proliferation and malignant cell adhesion to the BM stromal cells in MCL (Rinaldi et al., 2006; Bernard et al., 2015). Here, BTK is linked to mantle cell lymphoma.