One of the underlying mechanisms of this support could be the factors that are secreted by BM stromal cells and mediate the survival of malignant B-cells in FL, as it has been shown that adhesion of lymphoma cells to BM stromal cells triggers the secretion of B cell-activating factor (BAFF) by BM stromal cells and BAFF, in turn, acts as a survival factor for malignant B-cells (Lwin et al., 2009). This evidence concerns the gene TNFSF13B and lymphoma.