Compared with EL4 + GM, C26 + GM-treated myotubes displayed a significant reduction in the phosphorylation of Akt (S473) (p = 0.025) and rpS6 (S240/244) (p < 0.001); both EL4 + GM (p = 0.047) and C26 + GM (p < 0.001) tumor-derived factors significantly reduced the phosphorylation of 4E-BP1 (T37/46) (Figures 1F,J). Here, RPS6 is linked to neoplasm.