Because nuclear translocation of YAP1 is modulated by the Wnt/β-Catenin pathway in melanoma-associated fibroblasts (Liu et al., 2019) and YAP1 is necessary to transactivate FSTL3 gene expression (Figure 3F), we hypothesized that elevated FSTL3 expression modulates β-Catenin signaling in CRC. This evidence concerns the gene FSTL3 and melanoma.