Because of the fact that β-Catenin can induce YAP1, and YAP1 is able to transactivate FSTL3, we curiously investigated a possible impact of abundant FSTL3 on β-Catenin signaling in CRC and found not only elevated β-Catenin expression levels, but also increased β-Catenin nuclear translocation in FSTL3 overexpressed cells, suggesting a positive feedback loop. This evidence concerns the gene YAP1 and colorectal carcinoma.