Additionally, survival analysis was further performed using the data of GEPIA and ENCORI databases, the samples were stratified into high and low ORC6 expression groups based on the median value of ORC6 expression, and it was demonstrated that high expression of ORC6 was associated with a detrimental prognosis of HCC patients (Supplementary Figures 1H,I). Here, ORC6 is linked to hepatocellular carcinoma.