ORC6 and hepatocellular carcinoma: What is more, the reanalysis of the HCC gene expression profile data from the GEO database (GEO accession no: GSE84402 and GSE101685) indicated that ORC6 expression was markedly upregulated in HCC tissues, especially the HCC tissues in T1 and T3 stages compared with normal liver tissues (Supplementary Figures 2A–D).