Moreover, compatible with KIT regulating the expansion of EMPs with their intrinsic myeloid potential, gain-of-function mutations have been associated with human adult and pediatric core binding factor acute myeloid leukemia (CBF-AML), for which KIT mutations are poor prognostic factors (Cairoli et al., 2006; Krauth et al., 2014; Chen et al., 2018). Here, KIT is linked to acute myeloid leukemia.