The higher level of AGEs due to high glucose present in DM, aging or hyperglycemic patients, combined with the Ang II-dependent overexpression of RAGE will lead to a subsequent hyperactivation of the AGEs-RAGE signaling pathway with overproduction of ROS and IL-6 (251, 318), that may add to the sustained pro-inflammation of the lung, responsible for the ARDS. Here, IL6 is linked to diabetes mellitus.