POMC and obesity due to melanocortin 4 receptor deficiency: Examples of genetic analysis linked to precision medicine are seen in the investigation of the multiple causes of short stature, including epigenetic defects, syndromic growth failure and the search for causative genetic variants of obesity of endocrine—either pro-opiomelanocortin (POMC) deficiency or leptin receptor (LEPR) deficiency obesity—or syndromic origin (17, 41, 45, 48–52).