TILs are immune cells that are triggered by the host's immune response to the tumor; including T cells (CD4+ T helper lymphocytes/ Th, CD8+ cytotoxic T lymphocytes/ CTLs, and FOXP3+ regulatory T-cells/ Tregs), macrophages, dendritic cells, and mast cells (1,12,13). This evidence concerns the gene CD4 and neoplasm.