However, it has been identified that some tumor-derived Treg cells with the tumor antigen specificity could recognize the autologous antigen-specific tumor cell and secret interferon-gamma (IFN-γ) in vitro (5,24).On the contrary, we found three studies that explain the correlation of high TILs and poor prognosis in NPC. The gene discussed is IFNG; the disease is nasopharyngeal carcinoma.