CD4 and nasopharyngeal carcinoma: EBV positive NPC contains significantly more CD3+, CD4+, and CD8+ TILs than EBV negative NPC.In the whole NPC group, increased CD8+ count is associated with better OS (HR: 0.219. 95%CI: 0.075-0.640), but also in cases with PDL1 co-expression (HR: 0.073, 95%CI: 0.010-0.556).In EBV positive NPC co-expression of CD8+ and PDL-1 showed better DFS (HR:0.407, 95%CI: 0.195-0.850) and OS (HR 0.170, 95%CI: 0.037–0.787).