This could explain the increased transcriptional expression levels of PKG and PfCDPK5 in the PfCDPK1 mutants as mentioned above, suggesting an integrated cross-talk among kinases in malaria parasites (Bansal et al., 2016), including their role in Ca2+ mobilization in gametocyte activation of P. berghei and egress of merozoites in P. falciparum (Brochet et al., 2014). Here, PRKG1 is linked to malaria.