PRKG1 and malaria: This lower activity seems to be compensated by PKG, influencing the up-regulation of transcription levels of CDPK5 and CDPK6 in the CDPK1 T145M mutant parasites (Bansal et al., 2016), suggesting that a Ca2+- based signaling may modulate a very collaborative role in the CDPK family and other kinases in malaria parasites (Green et al., 2008; Brochet et al., 2014).