The P. falciparum-infected erythrocytes activate the FcRL5+T-bet+ B cells to release the anti-PS autoantibodies, which then bind to uninfected erythrocytes and induce the erythrocyte clearance, leading to anemia (Fernandez-Arias et al., 2016; Rivera-Correa et al., 2019). The gene discussed is FCRL5; the disease is anemia (phenotype).