Entamoeba histolytica trophozoites use cysteine proteases and glycosidases to cleave MUC2 mucin to breach the mucus layer and colonize the colon by using their surface lectin to bind with high affinity to mucin, causing intestinal amoebiasis (Moncada et al., 2003; Lidell et al., 2006; García et al., 2015; Nakada-Tsukui and Nozaki, 2016). This evidence concerns the gene MUC5AC and amebic dysentery.