TIGIT and neoplasm: In addition to inhibition of the recruitment of TILs to the tumor, F. nucleatum activates the T and natural killer (NK) cells inhibitory receptors TIGIT and CEACAM1, leading to a reduction in their ability to kill tumor cells (Gur et al., 2015; Brewer et al., 2019; Gur et al., 2019b; Galaski et al., 2021).