The sensitivity of TERT promoter mutation assessed using urine liquid biopsy was relatively high, ranging from approximately 50% to 70% for UBC and 30–50% for UTUC (Figure 3A) (8, 57, 62, 80–87), which was consistent with the frequency of TERT promoter mutations in UC tissues (Figure 1). Here, TERT is linked to renal pelvis/ureter urothelial carcinoma.