We selected previous reports with a large number of cases or with seminal initial significance and analyzed the association of frequency of TERT C228T mutation in entire TERT promoter mutation and that of TERT promoter mutation in various types of tumor specimens [melanoma (21, 22, 24–28), glioblastoma (29–35), HCC (23, 36–41), papillary thyroid carcinoma (42–48), UBC (23, 49–58), and UTUC (23, 59)] (Figure 1). This evidence concerns the gene TERT and differentiated thyroid carcinoma.