KD of HDAC3 upregulates miR-449 and downregulates c-MET expression, which inhibits tumour growth; KD of HDAC3 upregulates E-cadherin expression and reduces cell migration; HDAC3 interacts with ERα and form the HDAC3-ERα complex, which suppresses selective apoptosis mediated by TNF-α (93, 94, 98). The gene discussed is MET; the disease is neoplasm.